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Search Results for " glioblastoma multiforme "

18

Compounds

Cat No. Product Name Synonyms Targets
T7008 Vacquinol-1 Vacquinol 1 JNK
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
T16754 RIPGBM Apoptosis
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).
T77706 4-Borono-L-phenylalanine (s)-2-amino-3-(4-boronophenyl)propanoic acid,L-p-Boronophenylalanine Others
4-Borono-L-phenylalanine has antitumor activity and may be used in clinical trials of boron neutron capture therapy for the treatment of melanoma and glioblastoma multiforme.
T21463 Temozolomide Acid TMZA Others
Temozolomide Acid (TMZA) is a metabolite of temozolomide (TMZ). Temozolomide processes anticancer activity in vitro. Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocyt...
T2116 AEE788 NVP-AEE 788 Apoptosis , EGFR , c-Fms , FLT , Bcr-Abl
AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
T11118 Duocarmycin SA Others
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastom...
TP1589L EGFRvIII peptide PEPvIII acetate Others
EGFRvIII peptide PEPvIII acetate is a tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms and enhances tumorigenicity.
T63797 PDZ1i
PDZ1i is a potent MDA-9/Syntenin-specific inhibitor that crosses the blood-brain barrier. PDZ1i inhibits key GBM (glioblastoma multiforme) signaling, including FAK and EGFRvIII, and reduces MMP secretion.
T36100 K-TMZ
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lin...
T35542 LLP-3
Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a ...
T78771 Tubulin inhibitor 36
Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells, reflected by an IC50 value of 1.5±0.1 μM. Exhibiting significan...
T68663 GPI-15427
GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiform...
T76911 Asunercept
Asunercept (APG101; CAN008), a soluble CD95-Fc fusion protein, selectively targets and binds to CD95L, effectively disrupting CD95/CD95L signaling. It is utilized in research for treating glioblastoma multiforme (GBM), m...
T72832 MDM2-p53-IN-16
MDM2-p53-IN-16 is a potent inhibitor of the MDM2-p53 complex, exhibiting an IC 50 value of 4.3 nM for the dissociation of the human p53/MDM2 complex. It effectively reactivates p53, leading to apoptosis and cell-cycle ar...
T60348 N1,N11-Diethylnorspermine
N1,N11-Diethylnorspermine (DENSPM), a spermine analog, serves as a potent anticancer agent by activating polyamine catabolism, which in turn triggers cytochrome c release from mitochondria and activates caspase 3. This p...
T83716 KSL-128114 TFA Ac-rRrGrKkRrSHWX1X2DI-OH (X1=tert-Leucine; X2=Cyclohexylglycine)
KSL-128114, a peptide inhibitor of the membrane regulator syntenin (Ki = 300 nM), notably diminishes the viability of A2058 melanoma and patient-derived glioblastoma multiforme (GBM) cells in a concentration-dependent ma...
T72658 CRIPGBM chloride
cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-...
T79642 IV-275 Epigenetic Reader Domain
IV-275 is a dual inhibitor targeting the bromodomains of both BRG1 and BRM. This compound not only augments DNA damage when combined with Temozolomide and Bleomycin but also suppresses the invasiveness of GBM cells. Furt...
TargetMol